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These rats had been intravenously administered M1 (2 mg/kg) or M1 (2 mg/kg) combined with Mdivi-1 (one.two mg/kg) previous to ischemia, during ischemia or within the onset of reperfusion. We confirmed that administration of M1 by yourself or together with Mdivi-one previous to ischemia, in the course of ischemia or for the onset of reperf